Catalytic Asymmetric Hiyama Cross-Couplings of Racemic α-Bromo Esters

The first catalytic asymmetric cross-coupling of α-halo carbonyl compounds with aryl metal reagents has been developed, thereby generating synthetically useful α-aryl carboxylic acid derivatives in good enantiomeric excess. The method can also be applied to enantioselective alkenylation reactions.