A Learning Health System Approach to the COVID-19 Pandemic: System-Wide Changes in Clinical Practice and 30-Day Mortality Among Hospitalized Patients

Introduction: Rapid, continuous implementation of credible scientific findings and regulatory approvals is often slow in large, diverse health systems. The COVID 19 pandemic created a new threat to this common 9slow to learn and adapt9 model in healthcare. We describe how UPMC committed to a rapid learning health system (LHS) model to respond to the COVID 19 pandemic. Methods: An observational cohort study was conducted among 11,429 hospitalized patients from 22 hospitals (PA, NY) with a primary diagnosis of COVID 19 infection (March 19, 2020 to June 6, 2021). Sociodemographic and clinical data were captured from UPMC electronic medical record (EMR) systems. Patients were grouped into four time-defined patient 9waves9 based on nadir of daily hospital admissions, with wave 3 (September 20, 2020 to March 10, 2021) split at its zenith due to high volume with steep acceleration and deceleration. Outcomes included changes in clinical practice (e.g., use of corticosteroids, antivirals, and other therapies) in relation to timing of internal system analyses, scientific publications, and regulatory approvals, along with 30-day rate of mortality over time. Results: Mean (SD) daily number of hospital admissions was 26 (28) with a maximum 7 day moving average of 107 patients. System wide implementation of the use of dexamethasone, remdesivir, and tocilizumab occurred within days of release of corresponding seminal publications and regulatory actions. After adjustment for differences in patient clinical profiles over time, each month of hospital admission was associated with an estimated 5% lower odds of 30 day mortality (adjusted OR = 0.95, 95% confidence interval: 0.92 to 0.97, p < .001). Conclusions: In our large LHS, near real-time changes in clinical management of COVID 19 patients happened promptly as scientific publications and regulatory approvals occurred throughout the pandemic. Alongside these changes, patients with COVID 19 experienced lower adjusted 30 day mortality following hospital admission over time.