Application of diffusion tensor imaging in AIDS patients with brain opportunistic diseases: A comparative study of tuberculosis and toxoplasmosis☆

Abstract Objective This paper aims to discuss the diagnostic value of quantitative DTI on AIDS patients with brain tuberculosis or toxoplasmosis. Materials and methods 22 subjects (12 with brain tuberculosis and 10 with toxoplasmosis) were recruited, who underwent routine MRI, T1WI-CE and DTI imaging sequence. The morphological characteristics of lesions were observed, and FA and ADC values of the solid areas, edematous areas and the contralateral normal areas of the lesions were calculated. Results were compared by one-way ANOVA and independent sample t -test. The TB diagnosis efficiency of these two values was analyzed by ROC curve. Results ADC and FA values were detected with significant differences among the three regions between subjects with brain tuberculosis and subjects with toxoplasmosis ( P P P P Conclusions Quantitative DTI is valuable for diagnosis and differential diagnosis of patients with AIDS-associated infections, and also could provide references for clinical physicians for proper medications. The quantitative FA value could help better reveal different changes of microstructural integrity between different opportunistic infections.