Hepatic artery infusion for recurrent or chemotherapy-resistant hepatic malignancy.

e14151 Background: Previously treated hepatic colorectal metastases (CRC) and advanced hepato cellular cancer (HCC) are tumor challenges frequently unresponsive to systemic chemo therapy (CT). We reviewed survival outcome in chemo-resistant/high-risk patients following hepatic artery infusion (HAI) in 21 CRC pts, 10 HCC pts, and 6 miscellaneous metastatic cancers. Methods: Patient groups: 21 CRC pts (16M, 5 F), mean age 63, 16 had metachronous (DFI-17 mos), and 5 synchronous CA; liver extent: 76% multiple (>5) mets or extensive bilateral, CEA (ng/m), >100, 8 pts > 50 (3 pts) < 5 (3 pts) and , NA – 7 pts. Previous CT: FU/LV (11pts), oxaliplatin (OX) or irinotecan (IR) (10 pts). Liver surgery: partial resection/RFA – 9 pts. HCC: (9 PTS), cholangio CA(1), M/F 5/5; av. age 63. Previous RX hepatic lobectomy 4 pts, RFA/TACE – 3 patients. Miscellaneous GP (therapy): Hepatic lobectomy + HAI were done in metastatic lung (1), Breast (1), advanced gall bladder cancer (GBCA; T 3-4; 2 pts); HAI alone was done in Br. C...