1227 Prenatal and Postnatal Child Exposure to Environmental Tobacco Smoke

Background: Environmental tobacco smoke exposure (ETS) is associated with poor pregnancy outcome including increases risk of spontaneous abortion, stilbirth, low birth weight, preterm delivery and sudden infant death syndrome. ETS exposure after birth can increase the risk of sudden infant death syndrome, respiratory infections, asthma, middle ear diseases or even cancer and it can cause neurodevelopmental and behavioural problems in children. The aim of the study was to evaluate the prenatal and postnatal child exposure to environmental tobacco smoke. Material and Methods: The study population consisted of 150 women from Lodz, Poland among which detail questionnaires were conducted three times during pregnancy period. From all women included into the study the saliva sample was collected to verify smoking status in pregnancy. One and two years after delivery additional questionnaires were performed and urine sample from all children was collected. The cotinine level in saliva and urine was analyzed using Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS ESI+). Results: About 22% of the children were expose to ETS during prenatal and 46% in postnatal period. Cotinine level in children's urine statistically differentiated children from smoking mothers (geometric mean (GM) 11.4 ng/ml; 95% CI 7.1-18.3) and in exposed homes (GM 7.3 ng/ml; 95% CI 3.6- 15.0) compared with non-exposed homes (GM 1.3 ng/ml; 95% CI 0.9-1.7) (p< 0.001). Conclusions: Children should be more protected from ETS exposure in prenatal and postnatal period.