Effects of Rhythm and Rate-Controlling Drugs in Patients With Permanent His-Bundle Pacing

Introduction: Antiarrhythmic drug therapy can affect pacemaker parameters in both the atrial and ventricular myocardium. It is not known whether antiarrhythmic drugs impact His bundle pacing/sensing parameters and His to ventricle (H-V) intervals following permanent His bundle pacing (HBP). The aims of the study were to prospectively determine the influence of rhythm and rate-controlling drugs on pacing parameters and H-V conduction after His bundle lead implantation and to assess the impact of rhythm and rate-controlling drugs on the safety of HBP. Materials and Methods: Patients (N=140) with QRS duration 0.05). The HV interval was not affected except in the large-dose propafenone group where HV interval prolonged (P=0.001). All patients maintained 1:1 H-V conduction following drug administration. Conclusion: There was no adverse impact on the HBP parameters or H-V conduction after the administration of commonly used dosage of rhythm and rate-controlling drugs. The drugs were safe in patients with permanent His bundle pacing.