Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Hongmei Li,Theodros Asberom,Thomas A. Bara,John W. Clader,William J. Greenlee,Hubert B. Josien,Mark D. McBriar,Amin A. Nomeir,Dmitri A. Pissarnitski,Murali Rajagopalan,Ruo Xu,Zhiqiang Zhao,Lixin Song,Lili Zhang

Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

2007

Hongmei Li
Theodros Asberom
Thomas A. Bara
John W. Clader
William J. Greenlee
Hubert B. Josien
Mark D. McBriar
Amin A. Nomeir
Dmitri A. Pissarnitski
Murali Rajagopalan
Ruo Xu
Zhiqiang Zhao
Lixin Song
Lili Zhang

Abstract Development of cis -2,4,6-trisubstituted piperidine N -arylsulfonamides as γ-secretase inhibitors for the potential treatment of Alzheimer’s disease (AD) is reported.

Keywords:

Chemical synthesis
Organic chemistry
Aspartic Endopeptidases
Enzyme
Amyloid precursor protein secretase
Alzheimer's disease
Piperidine
Amyloid precursor protein
Biochemistry
Chemistry
Enzyme inhibitor
Stereochemistry
γ secretase

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