Acute Myeloid Neoplasms

Genetic profiling has been central to the diagnosis and taxonomy of hematopoietic neoplasms for over a decade. Acute myeloid leukemias are a heterogeneous subgroup of myeloid neoplasms with an aggressive clinical course, and the majority of these cases are defined by their underlying genetics. Cytogenetic evaluation retains a primary role in the evaluation and subclassification of these entities, but incorporation of molecular sequencing data has quickly become increasingly important for diagnosis, prognosis, and clinical management.