Prospective Blinded Evaluation of Gd-DOTA– versus Gd-BOPTA–enhanced Peripheral MR Angiography, as Compared with Digital Subtraction Angiography

PURPOSE: To compare the diagnostic accuracy of gadobenate dimeglumine (Gd-BOPTA)–enhanced versus gadoterate meglumine (Gd-DOTA)–enhanced magnetic resonance (MR) angiography in patients with peripheral arterial occlusive disease (PAOD). MATERIALS AND METHODS: Fifty-six patients underwent MR angiography enhanced with either Gd-DOTA (28 patients) or Gd-BOPTA (28 patients). All arterial segments from the renal arteries to the distal run-off vessels were evaluated for disease severity. The sensitivity, specificity, and accuracy of MR angiography enhanced with both agents separately were evaluated with a paired t test; digital subtraction angiography was the reference standard. Interobserver variability was assessed by using the Cohen test. RESULTS: Diagnostic MR angiograms were obtained in all 56 patients. Overall, sensitivity and specificity of Gd-DOTA–enhanced MR angiography were 96% and 93%, respectively, for observer 1 and 96% and 85%, respectively, for observer 2 (κ = 0.82). Corresponding values for Gd-BO...