Effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan and theophylline in patients with metastatic castration-resistant prostate cancer

Kim N. Chi,Anthony W. Tolcher,Peter Lee,P. J. Rosen,Christian Kollmannsberger,K. Papadopoulos,Amita Patnaik,Arturo Molina,Juhui James Jiao,Catherine Pankras,Brianne Kaiser,Apexa Bernard,Namphuong Tran,M. Acharya

Effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan and theophylline in patients with metastatic castration-resistant prostate cancer

2013

Kim N. Chi
Anthony W. Tolcher
Peter Lee
P. J. Rosen
Christian Kollmannsberger
K. Papadopoulos
Amita Patnaik
Arturo Molina
Juhui James Jiao
Catherine Pankras
Brianne Kaiser
Apexa Bernard
Namphuong Tran
M. Acharya

Purpose To assess the effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan HBr (CYP2D6 substrate) and theophylline (CYP1A2 substrate) in patients with metastatic castration-resistant prostate cancer (mCRPC).

Keywords:

Prostate cancer
Prednisone
Abiraterone acetate
Castration
Theophylline
Dextromethorphan
Pharmacology
CYP2D6
Pharmacokinetics
Medicine
CYP1A2

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