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Changes in blood content of prostaglandin F2α and leukotrienes C4 and B4 in rats after intravenous injection of contrast agents
1997
It is shown that Triombrast=Hexabrix=Omnipaque≤Melitrastprostaglandin F2α and leukotrienes C4 and B4 in the blood of sensitive rats (50%) 15 min after intravenous injection of the preparation, the changes in prostaglandin F2α being maximal, while those in leukotrienes C4 minimal. The effect of nonionic contrast agents on the blood level of prostaglandin F2α (0.1–2.0 g I/kg, except for Omnipaque) and leukotriene B4 (in a dose of 0.5 g I/kg) is more pronounced in comparison with the ionic preparations.
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