Evaluation of platelet-rich plasma and fibrin matrix to assist in healing and repair of rotator cuff injuries: A systematic review and meta-analysis

Objective:To perform a meta-analysis examining the effectiveness of platelet-rich plasma and platelet-rich fibrin matrix for improving healing of rotator cuff injuries.Data sources/design:A meta-analysis of eligible studies was performed after searching Medline, Cochrane, and EMBASE on 14 December 2015.Setting:University hospital.Participants:Patients with rotator cuff injuries.Review methods/intervention:Databases were searched using the keywords “PRP or platelet-rich plasma,” “PRFM or platelet-rich fibrin matrix,” “rotator cuff,” and “platelet-rich” for studies comparing outcomes of patients with rotator cuff injuries that did and did not receive a platelet-rich product.Main measures:The primary outcome was a functional score change from pre- to post-treatment (Scorepost–Scorepre). The secondary outcome was a visual analogue scale (VAS) pain score change from pre- to post-treatment (VASpost–VASpre).Results:A total of 11 studies were included in the meta-analysis. The total number of patients that receiv...