Late Breaking Abstract - Risk factors of mortality for COVID-19 patients in a North East London cohort: a retrospective analysis

Background: There is a growing body of literature on COVID-19 suggesting decreased survival with increasing age, in black and minority ethnic patients (BAME), and with comorbidities such as diabetes mellitus and obesity Aims: To evaluate whether these risk factors were relevant in a cohort of COVID-19 patients admitted to a large North East London NHS trust serving 3 boroughs with a highly diverse population Method: Data was collected for 215 patients from 10/03/2020-26/04/2020 for retrospective analysis 209 patients with confirmed or clinically suspected COVID-19 admitted to 3 respiratory wards were included in the final analysis Results: Most patients were male (66 0%) 77 patients died during the data collection period (32%) 32 4% of patients had pre-existing diabetes, and 14 4% had pre-existing obesity 118 patients were of White ethnicity (56 5%), 43 Asian (20 6%), 28 Black (13 4%), 4 Mixed (1 9%) and 16 Other (7 7%) In a Cox proportional hazards model, there was a significant difference in survival for patients >65 years old (HR 6 12, 2 20-17 1, p < 0 001) There was a no significant difference in survival for patients based on sex, pre-existing diabetes, obesity or ethnicity Conclusion: In contrast to international data and despite serving a population with rich ethnic diversity, COVID-19 infection in our cohort was most prevalent in white patients The unchanged survival between white and BAME groups may reflect the high measures of deprivation in the local population To better understand these findings continued investigation into the local demographics and variations are critical to stratify risk and to help plan for further peaks in the pandemic