The illustration of the successful mobilization of hematopoietic stem cells using plerixafor and pegfilgrastim in the patient with non-hodgkin's lymphoma

In our clinical example, we studied the possibility of early treatment intensification, through the use of a new combination pegfilgrastim and plerixafor as a regime of mobilization. Within 4 days (after a single injection pegfilgrastim 6 mg in D1) we observed a gradual increase in the content of CD34+-cells in peripheral blood, but only after injection plerixafor (D4) at a rate of 0.24 mg/kg, we were able to initiate the apheresis procedure. Number of collected CD34+-cells was 14,9106 that is more than adequate for a quick and stable hematopoietic recovery after a course HDC and timely recovery of the cellular composition of the blood of this patient (D10) indicated the quality of hematopoietic assembled material. Thus, the combination pegfilgrastim and plerixafor - a simple and effective way to mobilize hematopoietic stem cells in peripheral blood.