Synthesis based on affinity separation : A new methodology for high-throughput synthesis using affinity tags

A new "tag" strategy, termed "synthesis based on affinity separation (SAS)", was developed for high throuput synthesis of organic compounds. In this method, the desired tagged compound was separated from the reaction mixture by solid-phase extraction using specific molecular recognition. The interaction between a crown ether (32-crown-10) and ammonium ion and the interaction between a barbituric acid derivative and its artificial receptor were used for SAS.