Engineering nucleases for gene targeting: safety and regulatory considerations
2014
Nuclease-based gene targeting (NBGT) represents a significant breakthrough in targeted genome editing since it is applicable from single-celled protozoa to human, including several species of economic importance. Along with the fast progress in NBGT and the increasing availability of customized nucleases, more data are available about off-target effects associated with the use of this approach. We discuss how NBGT may offer a new perspective for genetic modification, we address some aspects crucial for a safety improvement of the corresponding techniques and we also briefly relate the use of NBGT applications and products to the regulatory oversight.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
173
References
80
Citations
NaN
KQI