Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids

In a new study by Kamran Atabai and colleagues, the milk fat globule protein, Mfge8, is found to promote the uptake of dietary fat and the absorption of fatty acids by peripheral organs via activation of integrin signaling and the expression of fatty acid transporters. They also found that genetic deletion of Mfge8 protected mice from diet-induced obesity and insulin resistance.