Polymorphisms of VDR gene and risk of gastric cardiac adenocarcinoma in Chinese population

// Jun Yin 1, * , Huiwen Pan 1, * , Tao Long 1, * , Lu Lv 1 , Peng Zhai 1 , Chao Liu 1 , Aizhong Shao 1 , Yijun Shi 1 , Yangyong Sun 1 , Jingfeng Zhu 1 , Liming Wang 2 , Guowen Ding 1 , Suocheng Chen 1 , Weifeng Tang 1 , Cheng Qian 3 , Lijie Tan 3 and Haiyong Gu 1 1 Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China 2 Department of Chemotherapy, Cancer Institute, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China 3 Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, China * These authors have contributed equally to this work Correspondence to: Haiyong Gu, email: haiyong_gu@hotmail.com Jun Yin, email: yin912@outlook.com Lijie Tan, email: tan.lijie@zs-hospital.sh.cn Keywords: VDR polymorphisms, gastric cardiac adenocarcinoma, association Received: September 06, 2016     Accepted: March 29, 2017     Published: April 20, 2017 ABSTRACT Vitamin D receptor ( VDR ) gene polymorphisms have been reported to increase susceptibility to some malignant tumors, yet the effect on gastric cardiac adenocarcinoma susceptibility remains unknown. Here, we conducted a hospital-based case-control study to examine the correlation of single nucleotide polymorphisms of VDR rs2107301T>C, rs2228570C>T, rs1989969C>T and rs11568820 G>A and gastric cardiac adenocarcinoma susceptibility. A total 330 cases and 608 controls were enrolled in the study. Using ligation detection reaction, we found that the variant alleles of the four polymorphisms were not associated with risk of gastric cardiac adenocarcinoma. Further stratified analyses showed that there was an increased risk associated with VDR rs1989969 polymorphism among patients who were drinking or aged <60. The haplotypes VDR T rs2107301 T rs2228570 C rs1989969 G rs11568820 reduced the susceptibility. This study demonstrated that VDR rs1989969 polymorphism was involved in the carcinogenesis of gastric cardiac adenocarcinoma, especially increased the risk in the younger and alcohol drinking Chinese population.