Analysis of the characteristics of bacterial infection and antibiotic resistance in patients in the ICU.

Objective To analyze the types,rate of detection,distribution,and drug resistance of pathogens in patients with infections in a hospital ICU in order to provide an etiological basis for clinical care and control of infection in the ICU.Methods In accordance with the standards of the National Clinical Laboratory Procedures,specimens from patients were inoculated into medium and pathogens were isolated.The Microscan-Walkaway40 automatic microbial analyzer (US) was used to identify pathogens and analyze their drug resistance.Phenotypic confirmation as recommended by the NCCLS was used to detection ESBLs and MRSA.Results Patients with infections in the ICU mainly had respiratory tract infections.In 1 year,216 pathogens were isolated;of these,50 were Gram-positive cocci,accounting for 23.1%,and 24 were fungi,accounting for 11.1%.Pseudomonas aeruginosa was the main Gram-negative bacilli,accounting for 28.2%,and coagulase-negative staphylococci was the main Gram-positive cocci,accounting for 80.0%.Candida albicans was the main fungus,accounting for 75.0%.Gram-negative bacilli had higher rates of resistance to ampicillin and lower rates of resistance to vancomycin,PICI/Tazo,and amikacin.Gram-positive bacteria had higher rates of resistance to erythromycin and sensitivity to vancomycin,linezolid,and Synercid.Candida albicans had a rate of resistance rate to 7 kinds of commonly used antifungals of 0-28%.Conclusion ICU patients are prone to respiratory infections.Bacterial infections are mainly caused by Gram-negative bacilli and most strains are highly resistant and have multiple drug resistance.