Enhanced Transmission through Gold Nanohole Arrays Fabricated by Thermal Nanoimprint Lithography for Surface Plasmon Based Biosensors

Abstract We present the fabrication of gold nanohole arrays using thermal nanoimprint lithography and integration into a microfluidic device for detection of biological analytes. The biosensor makes use of a surface-plasmon mediated effect known as enhanced optical transmission, in which the transmission of light is modulated. The sensitivity achieved with these gold nanohole arrays has been characterized and up-to 300 RIU/nm were obtained varying the array parameters. Detection of protein biomarkers via capture by specific antibodies has been achieved demonstrating the biosensing capabilities of the fabricated devices.