The Expression of bax and p~(16) gene in colon tumor and their clinicopathological significance

Objective:To determine the relationship between the expression of p 16 and bax gene in colon carcinoma and their clinicopathological significance and prognosis.Methods:immunohistochemical LSAB method was used to evaluate monoclone antibody of p 16 and bax gene in 64 cases of colon carcinoma.Results:The positive rates of bax and p 16 in colon carcinoma were54.6% and 48.4% respectively,positive rate of p 16was significant difference in survival (x 2=4.23,P0.05)and between well differentiated and poorly groups of tumor (x 2=13.12,P0.05).The positive-staining rate of bax was significant different at different Dukes stage(x 2=4.16,P0.05).Conclusion:The expression rate of p 16 and bax gene was very high in colon carcinoma,and it might have a prognosis implications in patients with colon carcinoma.