A phase I/II multiple expansion cohort trial of MRTX849 in patients with advanced solid tumors with KRAS G12C mutation.

Kyriakos P. Papadopoulos,Sai-Hong Ignatius Ou,Melissa Lynne Johnson,James Christensen,Karen Velastegui,Diane Potvin,Demiana Faltaos,Richard C. Chao

A phase I/II multiple expansion cohort trial of MRTX849 in patients with advanced solid tumors with KRAS G12C mutation.

2019

Kyriakos P. Papadopoulos
Sai-Hong Ignatius Ou
Melissa Lynne Johnson
James Christensen
Karen Velastegui
Diane Potvin
Demiana Faltaos
Richard C. Chao

TPS3161Background: RAS proteins are part of the family of small GTPases which regulate intracellular signaling pathways responsible for cell growth, migration, survival and differentiation. Oncogen...

Keywords:

KRAS
Pathology
Cohort
Oncology
Internal medicine
Mutation
Medicine
in patient
intracellular signaling pathways
Cancer research
GTPase
Cell growth
phase i ii

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