The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells
2014
Immune evasion is a hallmark of cancer. We recently identified the adhesion molecule L1CAM as biomarker of pancreatic ductal adenocarcinoma (PDAC) associated with poor prognosis. During inflammation-associated carcinogenesis, L1CAM drives the enrichment of highly immunosuppressive CD4+CD25-CD69+ T cells. Thus, L1CAM may serve as a target in immunomodulatory therapy for PDAC.
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