PIM1 and MYC: a changing relationship?

PIM protein kinases have been known for some time as oncogenes that promote lymphomagenesis together with MYC (c-Myc). It is now reported that PIM1 is a coactivator of MYC, and it phosphorylates serine 10 of histone H3 at MYC target genes. These results may shed new mechanistic light on how PIM1 cooperates with MYC in tumorigenesis.