Low dose of dicyclomine associated with respiratory distress and death in an infant

Objective:To report a case of a low dose of oral dicyclomine associated with respiratory distress and death in an infant.Case Summary:A 35-day-old Malay boy was given a total of 1.0 mL of Colimix syrup (per 5 mL containing dicyclomine HCl 5 mg and simethicone 50 mg) by a general practitioner for vomiting. About 24 hours later, the boy was referred to the hospital because of abdominal distension and difficulty in breathing. On admission to the intensive care unit, the patient was unconscious, hypotensive, tachycardic, apneic, and cyanotic. His condition continued to deteriorate despite acute treatment and resuscitation, and the patient died about 72 hours later.Discussion:Metabolic disorder and septic shock were not likely and not convincing diagnoses considering the laboratory data and other patient information. Furthermore, this patient's condition deteriorated within a short time and did not respond to antibiotics and other drug treatments. Dicyclomine is highly suspected because the respiratory distres...