Local and systemic tolerance of flutrimazole skin creams following single and repeated topical application in healthy volunteers
1992
A double-blind, randomized phase I study was performed in 21 healthy volunteers evacuate the dermal tolerance of skin creams containing 1% and 2% 1-[(2-fluorophenyl) (4-fluorophenyl]phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) or only the excipient, versus a commercial skin cream containing 1% clotrimazole. The study was carried out using the patch-test procedure performed in three stages: 1. single application in the back skin
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