115 Association between uric acid serum and maternal and perinatal results in preeclampsia

Introduction Preeclampsia is a specific systemic disease of pregnancy with unknown etiology, but it is believed to be due to changes in the process of trophoblastic invasion, leading to an inadequate uterine blood supply and oxidative stress of the placental tissue. Increasing of maternal uric acid serum concentration (UA) in women with pre-eclampsia has been associated with the severity of hypertension, proteinuria and maternal and perinatal outcome on pregnancy. Objectives Identify the association between serum uric acid and adverse maternal and perinatal outcomes. More specifically, the correlation of maternal UA serum concentration with newborn size for gestational age and maternal proteinuria. Subjects and methods Cross observational study in pregnant women with pre-eclampsia, which were stratified according to dose of serum uric acid into two groups, as follow: I (below 6  mg/dL) and II (greater or equal to 6  mg/dL). Maternal and perinatal adverse outcomes were examined. Results were analyzed by T-Student and chi-square tests and correlations were evaluated by Pearson test. The level of significance used was 5%. Results In group II there were a greater frequency of hypertensive crisis, eclampsia, partial HELPP syndrome and HELLP syndrome. Also it were observed an increased number of small newborns for gestational age, lower weight of the newborn, the higher percentage of fetal death, prematurity and index Apgar at 1  min. Conclusions The results suggest that patients with higher uric acid have worse adverse outcomes both for the mother and the newborn. In conclusion, the dosage of maternal serum uric acid associated with other clinical and laboratory tests can help in obstetrical practice.