Itraconazole versus griseofulvin. A double-blind comparison in patients with tinea corporis and tinea cruris

The efficacy of two oral antifungal drugs, itraconazole and griseofulvin, in tinea corporis and tinea cruris was compared in a doubleblind trial. Patients were treated with itraconazole (n = 15, 100mg/day) or griseofulvin (n = 14, 500mg/day) for 2 weeks. The clinical outcome was in favour of itraconazole. After 2 weeks 60% of the patients treated with itraconazole were cured, and 21% of those treated with griseofulvin. Equivalent figures 2 weeks after the end of the treatment, were 67% and 29%, respectively. Both treatments were well tolerated.