Palliative treatment of bone pain related to prostatic cancer metastasis with Flutamide combined Bisphosphonates

Objective:To investigate the role of flutamide combined bisphosphates in the treatment of advanced prostates cancer patients complaining of bone pain due to metastasis.Methods:The clinical data of 19 cases of prostatic cancer with multiple skeletal complications were analyzed retrospectively.The flutamide was taken in by the patients at 5th day after receiving bilateral orchidectomy and other anticancer drugs or endocrine therapies were refused during the period of overdose.While the bisphosphates was taken in by the patients in case of bone pain due to metastasis occurred.Results:The osseous metastatic lesions areas were diminished differently and the lesions were decreased 65.7% after 6 months,65.9%after12 months.The odynolysis rates were 78.9%,83.5% and 65.9% after 3 months,6 months and 12 months respectively.The serum PSA level was also declined obviously.Conclusions:Flutamide combined bisphosphates are promising weapons for the management of advanced prostatic cancer related bone pain.It can relieve the patient's bone pain significantly and improve the survival quality.