Detección de regiones genómicas con elevado desequilibrio de ligamiento en poblaciones de vacuno de carne españolas con análisis de BovineHD BeadChip

The objective of this study was to evaluate the pattern of linkage disequilibrium along the genome in seven autochthonous Spanish cattle beef populations (Asturiana de los Valles, Avilena Negra-Iberica, Bruna dels Pirineus, Morucha, Pirenaica, Retinta and Rubia Gallega). The BovineHD BeadChip was used to genotype 171 trios of individual/sire/dam. 573,134 SNPs were available after filtering. With this information, a parameter that measures the mean disequilibrium of the genome in regions of 1 Mb in each population was defined. The results show that the linkage disequilibrium is very heterogeneous along the genome, and this heterogeneity is consistent among the considered populations. The causes of this heterogeneity could be structural, and attributed to a lower mutation rate and/or recombination rate, or a result of stabilizing selection.