Subcutaneous transposition of the spleen: Pharmacokinetic study of the intrasplenic route

When the spleen is properly isolated with amniotic membrane and implanted in the extra-abdominal cellular subcutaneous tissue, it may serve as an excellent route for administering drugs selectively to the liver. We have employed a biological method, the capacity of Adrianiycin ® to inhibit the growth of a strain of Bacillus subtilis,in order to evaluate the hepatic concentrations of the drug administered intravenously and intrasplenically. At 60 minutes or more after injection, there was an order of magnitude difference in favor of the intrasplenic route.