Immune surveillance by CD8αα + skin-resident T cells in human herpes virus infection

Herpes simplex virus 2-infected individuals are shown to have skin-tissue-resident CD8αα+ T cells that persist at the portal of virus release in genital skin and mucosa, possess oligoclonal T-cell-receptor-β CDR3 sequences that are stable over time, and express gene signatures of antiviral and cytolytic function indicative of viral-specific immune surveillance.