Quality by Design-Based Crystallization of Curcumin Using Liquid Antisolvent Precipitation: Micromeritic, Biopharmaceutical, and Stability Aspects

Sananda Som,Sachin Kumar Singh,Gopal Lal Khatik,Bhupinder Kapoor,Monica Gulati,Gowthamarajan Kuppusamy,Nandha Kumar Anandhakrishnan,Bimlesh Kumar,Ankit Kumar Yadav,Rajesh Kumar,Pankaj Singh,Rubiya Khursheed,Rajan Kumar,Narendra Kumar Pandey,Jivan Jyoti,Souvik Mohanta,Omji Porwal

Quality by Design-Based Crystallization of Curcumin Using Liquid Antisolvent Precipitation: Micromeritic, Biopharmaceutical, and Stability Aspects

2019

Sananda Som
Sachin Kumar Singh
Gopal Lal Khatik
Bhupinder Kapoor
Monica Gulati
Gowthamarajan Kuppusamy
Nandha Kumar Anandhakrishnan
Bimlesh Kumar
Ankit Kumar Yadav
Rajesh Kumar
Pankaj Singh
Rubiya Khursheed
Rajan Kumar
Narendra Kumar Pandey
Jivan Jyoti
Souvik Mohanta
Omji Porwal

Abstract The aim of present study was to introduce the role of quality by design to produce curcumin crystals with enhanced dissolution rate and bioavailability. The liquid antisolvent method was u...

Keywords:

Dissolution
Biopharmaceutical
Biochemistry
Crystallization
Chemical engineering
Curcumin
Biology
Bioavailability
Box–Behnken design
Quality by Design
enhanced dissolution

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