Development of a New DNA Chip Microarray Using RFSA Method

Microarray-based DNA chips provide architecture for multi-analyte sensing. In this paper, we report a new method in which minute particles are arranged in a random fashion on a chip pattern using random fluidic self-assembly (RFSA) method by hydrophobic interaction. We intend to improve the stability of the particles at the time of arrangement by establishing a wall on the chip pattern. Besides, distinction of an individual particle is enabled by giving a tag structure. This approach can be applicable as a new fabrication technology to develop a minute integration DNA chip microarray.