Prophylactic Antibiotics Versus Immunoglobulin Replacement in Specific Antibody Deficiency

J Hajjar, AL Nguyen, G Constantine. J Clin Immunol. 2020;40:158–164 To compare treatment outcomes in patients with specific antibody deficiency (SAD) who were treated with immunoglobulin replacement therapy (IGRT) and/or prophylactic antibiotics (PA). This study included 65 patients with SAD (mean age 18, range 2–71 years old) who were treated with IGRT and/or PA at two tertiary care centers in the United States. This was a retrospective chart review that evaluated clinical characteristics, laboratory findings, treatment patterns and clinical outcomes of patients with SAD who were treated with IGRT and/or PA. All patients were followed …