Impact nano- conjugate on Drosophila for early diagnosis of Alzheimer’s disease.

Alzheimer's disease (AD) is irreversible neurodegenerative disease. Recent identification of AD biomarkers leads to the diagnosis of AD before the stage of dementia. It has been showed that Drosophila melanogaster is a valuable model to study human neurodegeneration, including AD.According to its properties, curcumin represents a promising potential for the diagnosis of AD. In order to improve its use, new formulations, including nanotechnology-based delivery systems, have beenapplied. The current study aimed to diagnose AD by detecting the accumulation of amyloid beta-peptide via carbon dot-curcumin nanoparticle conjugation in Drosophila. The accumulation of amyloid beta-peptide has been detected via the conjugate using the fluorescence imagining technique. These results suggest that carbon dot-curcumin nanoparticle conjugation could be used as a diagnostic tool for AD.