GM-CSF Modulates Immune Function and Improves Survival After Thermal Injury

As a result of major advances in the care of thermally injured patients over the last two decades, mortality from hypovolemic shock, acute renal failure, and metabolic wasting has fallen dramatically. However, infection remains an important cause of morbidity and mortality in these patients [1]. The prevalence and severity of septic episodes is largely secondary to profound alterations in defence mechanisms which often characterise the host’s response to major burn injury.