Dual-Zwitterion Functionalized Ultra-Hydrophilic Metal-Organic Framework with Ingenious Synergy for Enhanced Enrichment of Glycopeptides

A rational strategy was introduced for the synthesis of novel dual functionalized metal-organic framework nanocomposite (AuGC/ZIF-8) with ultra-hydrophilicity to enhance the glycopeptides enrichment. The advantages of ingenious synergy, low-cost, facile and large-scale synthesis, and excellent enrichment performance will hold a bright future in nanomaterial synthesis, glycoproteomics analysis, and related biochemistry.