Anti-inflammatory activity of Guduchi Ghana (aqueous extract of Tinospora Cordifolia Miers.)

Background: Guduchi Ghana is one of the unique Ayuvedic classical preparation which is prepared from aqueous of extract of Guduchi ( Tinospora cordifolia Miers.) stem. It is one of the frequently used drugs to treat the Madhumeha , Pandu , Kamala , Amlapitta , Grahani , Kustha , Jirna Jwara and Viswamjwara , Trishna , Shool , Yakritavikara , etc. Looking to these indications, in market most of the Pharma industries prepared Guduchi Ghana by applying the various extraction process. Aim: To evaluate comparative anti-inflammatory activity of classically prepared and market sample of Guduchi Ghana . Materials and Methods: Both samples were evaluated for anti-inflammatory activity using carrageenan induced paw edema model in rats. Animals were divided in three groups, having six animals in each. Group A received test drug, Group B received market sample at a dose of 50 mg/kg orally, while Group C (control group) received tap water. Results: Reduction in edema was observed in Group A and B at 3 h interval by 33.06% and 11.71% respectively. Group A showed significant effects ( P Conclusion: These experimental results have shown anti-inflammatory activity of Guduchi Ghana .