The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid

Antonello A. Romani,Silvia Desenzani,Marina Morganti,Maria Cristina Baroni,Angelo F. Borghetti,Soliani P

The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid

2011

Antonello A. Romani
Silvia Desenzani
Marina Morganti
Maria Cristina Baroni
Angelo F. Borghetti
Soliani P

Purpose In TFK-1 and EGI-1 cholangiocarcinoma cell lines, zoledronic acid (ZOL) determines an S-phase block without apoptosis. Here, we investigated the occurrence of apoptosis stigmata when ZOL is associated to the BH3-mimetic ABT-737.

Keywords:

Cancer
Drug interaction
Growth inhibition
Pharmacology
Zoledronic acid
BH3 Mimetic ABT-737
Apoptosis
Programmed cell death
Medicine
Cell culture
In vitro

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