Design Integrated Microfluidic Chips for Clinical Applications

A biosensor is generally defined as an analytical device, which converts the biochemical responses into the quantifiable electronic signals. Its extensive utilities in medical diagnosis, toxicity testing, chemical analysis, food industry, and many other areas for quantitative assessments has appeared. Quartz crystal microbalance and field-effect transistor based devices have been demonstrated to possess exceptional characteristics and outstanding performance while conjugated with the advanced nanotechnology. However, both devices still have to face the nonspecific binding issue, which is a headache for researchers on all biosensor platforms. In our research, we have efficaciously reduce 95% nonspecific binding via immobilize the zwitterionic layer on the surface of the chip. Moreover, we integrate microfluidics, nanoparticles, rapid surface modification on several bio-sensing platforms to efficiently pretreat specimens and detect target biomolecules. In addition, a series advanced microfluidic ships are designed for lymphocyte isolation, active sperm sorting, and nanoparticle synthesis. Figure 1