Systemic Prolidase Activity and Oxidative Stress in Keratoconus

ABSTRACTAim: Our aim was to evaluate the serum prolidase activity, total antioxidant capacity (TAC) and total oxidant status (TOS) in patients with keratoconus.Material and method: A total 69 keratoconus patients and 72 control subjects with similar age and gender were evaluated within the scope of this study. The keratoconus group was divided into four stages with the modified Krumeich classification. Serum prolidase activity, TAC and TOS were measured and compared between the patient and control groups.Results: The median serum prolidase enzyme activity value was 528.3 (684.1–416.7) U/L in the keratoconus group and 606.2 (812.9–482.3) U/L in the control group. The difference between the groups was statistically significant (p = 0.027). The median TAC value was 1.24 (1.37–1.05) mmol/L in the keratoconus group and 1.29 (1.38–1.18) mmol/L in the control group. The median TOS value was 2 (4–1) μmol/L in the keratoconus group and 3 (4–2) μmol/L in the control group. There was no statistically significant dif...