CHANGES OF THE VAGINAL BIOCENOSIS IN CERVICAL DYSPLASIC LESIONS

REZUMAT CHANGES OF THE VAGINAL BIOCENOSIS IN CERVICAL DYSPLASIC LESIONS Elena Bernad1, Doru-Mihai Anastasiu1, Razvan Ilina2, Delia Hutanu3, Marius Virjan1, Cosmin Brisan4 Introduction: It is well known that disturbing vaginal biocenosis throught the presence of infectious factors can be blamed for the celular changes which precede the development of the lesional cervix. Material and methods: We have performed a study at the Bega University Clinic of Obstetrics and Gynecology, from Timisoara, between 01.07.2008-15.03.2009, on a number of 113 pacients with pathological results of the Babes-Papanicolaou cytology; we were also interested in the involvement of other infectious factors aside the human papilloma virus. Vaginal discharge samples were taken for bacterial tests and cultures. Results: In a large procentage of cases a clear disturbance of the vaginal biocenosis was observed, due to a variety of infectious factors – 41.6% of the pacients included in the cohort had positive bacteriological tests or cultures, 71% HPV infection from the investigated pacients. Furthermore, in the cohort with HSIL cytology we saw the greatest percentage of positive samples for pathological bacterial flora (63.6% of the pacients with HSIL cytology had a positive bacteriological test or culture), the lowest incidence of vaginal ecosistem alteration was observed in the pacients with ASCUS cytology (23.5%). Conclusions: Due to the association of pre-neoplasic processes with chronic genital inflamations, a regular examination with the discovery and treatment of vaginal infections is of utmost importance for the prevention of cancerous lesions.