Reduction of blood glucose and HbA1c levels by cyanidin 3,5-diglucoside in KKAy mice

Abstract Aronia melanocarpa has beneficial effects on lifestyle-related diseases. Our previous studies showed that dipeptidyl peptidase IV (DPP IV) activity was inhibited by cyanidin 3,5-diglucoside from aronia juice and the weight of adipose tissues of mice given aronia juice was also reduced. The aim of this study is to investigate the effects of cyanidin 3,5-diglucoside, including aronia juice, on type-2 diabetes through inhibition of DPP IV activity in vivo . Type-2 diabetes and obesity model KKAy mice were divided into three groups containing five mice in each group: a control group that was given water, an aronia group that was given aronia juice, and a cy-dg group that was given cyanidin 3,5-diglucoside solution. Although increased blood glucose and hemoglobin A1c levels were reduced in KKAy mice administered cyanidin 3,5-diglucoside, weight of white adipose tissue was not reduced. These results suggest that cyanidin 3,5-diglucoside has an anti-diabetic effect but not an anti-obesity effect.