Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70 TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity

Jadwiga Furmaniak,Jane Sanders,Jill Clark,Jane Wilmot,Paul W. Sanders,Yang Li,Bernard Rees-Smith

Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70 TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity

2019

Jadwiga Furmaniak
Jane Sanders
Jill Clark
Jane Wilmot
Paul W. Sanders
Yang Li
Bernard Rees-Smith

Background The human monoclonal autoantibody K1-70™ binds to the TSH receptor (TSHR) with high affinity and blocks TSHR cyclic AMP stimulation by TSH and thyroid stimulating autoantibodies.

Keywords:

Autoimmunity
Monoclonal
Endocrinology
Thyroid
Graves' ophthalmopathy
Graves' disease
Autoantibody
Antagonist
Internal medicine
Medicine
Receptor
Toxicity
Toxicology
Pharmacodynamics
Hormone
Pharmacokinetics

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations