Promising Antidiabetic and Wound Healing Activities of Forsskaolea tenacissima L. Aerial Parts

The aim of present study was to evaluate the antidiabetic activity of the total methanolic extract (TME) and different fractions of Forsskaolea tenacissima L. aerial parts with alloxan-induced diabetic rats and estimate its wound healing activity by excision wound model in rats as well as determine its toxicological activity by lethal dose 50 % (LD50). The ethyl acetate fraction showed a significant decrease in blood glucose level (36.00 %, P < 0.001) in comparison with glibenclamide (36.14 %, P < 0.001) as standard. The TME group showed marked increase in wound healing activity (97.9 %) compared with gentamycin standard group (96.8 %). The TME is considered safe due to its LD50, which was 7 g/kg body weight.