BASE DEFICIT DURING CITEIPC ARREST SECONDARY TO RESPIRATORY FAILURE IN IMMATURE PIGS

Recent studies suggest that NaHCO3 may be detrimental in treatment of cardiac arrest from ventricular fibrillation. The American Heart Association (AHA) recomnerds limited use of NaHCO3 (initial dose 1 mEq/kg). In children respiratory failure is the major cause of cardiac arrest; so these studies may not apply. The purpose of our study was to determine base deficit (-BE) at the time of cardiac arrest due to respiratory failure in immature pigs. 10 minipigs (8.0-9.5kg) were anesthetized with pentobarbital and ventilated. Catheters were placed in the aorta and pulmonary artery. The erdotracheal tubes were clamped (9.3±3.1 min) to produce asphyxia causing electromechanical dissociation (EMD) (Aortic pressure (PAo)<30 mmHg). (PAo), arterial blood gases and lactates were measured during a baseline (BL), at time of EMD and 3 min of EMD (EMD3)