M1 medulloblastoma should be considered high risk at any age

2016 Background: Metastatic (M) stage is an important prognostic marker in medulloblastoma. With current therapy including higher-dose craniospinal irradiation and dose intensive chemotherapy, older children with metastatic medulloblastoma have had improved survival. Some investigators have suggested that older children with M1 medulloblastoma be treated as average-risk patients. Additionally, the prognostic value of M1 disease in very young children has not been documented. Methods: We retrospectively reviewed the records of all newly diagnosed medulloblastoma patients treated at St. Jude Children’s Research Hospital from 1984 to 2006. Treatment generally included resection and chemotherapy. Older children received post-operative craniospinal and tumor bed irradiation; radiotherapy for younger children depended on treatment era and physician/family preference. We compared event-free and overall survival for patients with M1 disease to that of patients with M0 and M2/M3 disease for both age groups using t...