YH25448, a 3rd generation EGFR-TKI, in patients with EGFR-TKI-resistant NSCLC: Phase I/II study results.

9033Background: The epidermal growth factor receptor (EGFR) T790M mutation is one of the most common acquired resistance mechanism to EGFR tyrosine kinase inhibitors (TKIs). YH25448 is an oral, pot...