Bayesian estimation of cyclosporine clearance in bone marrow graft

The dosage regimen of cyclosporine (CsA) can be individualized in patients by means of a test dose (TD) method in the few days before bone marrow graft. To simplify the test dosing protocol, we used a Bayesian estimation (BE) of CsA clearance requiring population data and partial kinetic information for a given patient. The method can be used to calculate an individual CsA dosage regimen in real time. This real-time dosage regimen adjustment is more suitable, as it makes it possible to avoid the dependence phenomena of CsA kinetics over a long time period